Gentian is good for weak and/or painful digestion, loss of appetite, nausea, slow peristalsis, low vital energy, liver heat, detoxification, and acne. As a bitter tonic, gentian is taken 15-30 minutes before meals, usually in combination with other herbs. It has also been indicated for anemia, anorexia, and poor circulation. It is used as an anti-addiction herb (for instance, to stop smoking). Modern research shows that gentian has immune-activating properties, and it is commonly given to people who are recovering from long-term illnesses to improve assimilation of nutrients, energy levels, and immune function.